Our model is built using three levels: supracellular,
field potentials and CSDs (Current Source Density analysis) obtained
from the synchronous activity of a population of neurons; cellular,
morphology and physiology of the single neurons that make up the ensemble
and subcellular, electrotonic properties,
ionic active channels and calcium dynamics for each locus in the morphology.
The dorsal CA1 region was modeled with an aggregate
preserving an experimentally observed cell density of 42 neurons in a 50x50
µm lattice. The antero-posterior and latero-medial dimensions
of the aggregate were 1x1 mm corresponding to 16,966 morphologically identical
model neurons. The dimensions and cell number of the aggregate can
be taken as a estimation for the actual values for the dorsal CA1 region.
The spatial distribution of neurons was made
with their somata arranged in a realistic manner of 4 uneven layers with
66% of somata in the apical side and 22 and 11% in the two layers of the
basal side (see scheme in Figure 3, uneven, in Varona
et al. 2000 or simulation of the field potentials
and CSD analysis). The curvatures in the dorsal CA1 region were
neglected for this study.
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